Article

Pre-existing heterogeneity facilitates development of heteroresistance upon gene acquisition

2023-07-24

Abstract excerpt

Antibiotic resistance causes 1.27 million global deaths annually and is predicted to worsen. Heteroresistance is a form of resistance in which only a minor and unstable subpopulation of cells of a bacterial isolate are resistant to a given antibiotic, and are therefore often undetected by clinical diagnostics. These infrequent and undetected resistant cells can be selected during antibiotic therapy, expand in numb...

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Literature Corpus work: 9a5bc7fc-d635-5af0-ae23-9fb475564d52
DOI: 10.1101/2023.07.24.550411

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