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Article

Evolutionary paths to antibiotic resistance under dynamically sustained drug selection.

Nature genetics - 18 Dec 2011

Toprak Erdal, Veres Adrian, Michel Jean-Baptiste, Chait Remy, Hartl Daniel L, Kishony Roy

Abstract excerpt

Antibiotic resistance can evolve through the sequential accumulation of multiple mutations. To study such gradual evolution, we developed a selection device, the 'morbidostat', that continuously monitors bacterial growth and dynamically regulates drug concentrations, such that the evolving population is constantly challenged. We analyzed the evolution of resistance in Escherichia coli under selection with single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22179135
DOI: 10.1038/ng.1034
PMCID: PMC3534735

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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