Article

Copy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipeline

2022-06-07

Abstract excerpt

<h4>ABSTRACT</h4> It is unclear how bacteria rapidly adapt to resist novel drugs upon their introduction. Heteroresistance (HR) is a form of antibiotic resistance where a phenotypically unstable minority resistant subpopulation co-exists with a susceptible population. We observed HR to cefiderocol, a novel beta-lactam developed to resist beta-lactamases including extended-spectrum-beta-lactamases (ESBLs), among c...

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Literature Corpus work: 5702a132-7423-5fb1-b8e6-1ff6760d5aa8
DOI: 10.1101/2022.06.07.494873

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