ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro.

doi:10.1038/s41564-024-01891-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro.

Nature microbiology - 1 Feb 2025

Daruka Lejla, Czikkely Márton Simon, Szili Petra, Farkas Zoltán, Balogh Dávid, Grézal Gábor, Maharramov Elvin, Vu Thu-Hien, Sipos Levente, Juhász Szilvia, Dunai Anett, Daraba Andreea, Számel Mónika, Sári Tóbiás, Stirling Tamás, Vásárhelyi Bálint Márk, Ari Eszter, Christodoulou Chryso, Manczinger Máté, Enyedi Márton Zsolt, Jaksa Gábor, Kovács Károly, van Houte Stineke, Pursey Elizabeth, Pintér Lajos, Haracska Lajos, Kintses Bálint, Papp Balázs, Pál Csaba

Abstract excerpt

Despite ongoing antibiotic development, evolution of resistance may render candidate antibiotics ineffective. Here we studied in vitro emergence of resistance to 13 antibiotics introduced after 2017 or currently in development, compared with in-use antibiotics. Laboratory evolution showed that clinically relevant resistance arises within 60 days of antibiotic exposure in Escherichia coli, Klebsiella pneumoniae,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acinetobacter baumannii

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacteria

Share to Drug Resistance, Multiple, Bacterial

Share to Gastrointestinal Microbiome

Share to Gram-Negative Bacteria

Share to Klebsiella pneumoniae

Share to Metagenomics

Share to Pseudomonas aeruginosa

Source

Open in PubMed Open full text

Identifiers

PMID: 39805953
DOI: 10.1038/s41564-024-01891-8
PMCID: PMC11790497

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ESKAPE pathogens rapidly develop resistance against antibiotics in development in vitro.PMID 39805953Read ↗

Antibiotics of the future are prone to resistance in Gram-negative pathogensSemantic proximity Read ↗

Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative ReviewSemantic proximity Read ↗

Extracting novel antimicrobial emergence events from scientific literature and medical reportsSemantic proximity Read ↗

A global repository of novel antimicrobial emergence eventsSemantic proximity Read ↗

Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patientSemantic proximity Read ↗

A preclinical resistance framework discovers the virulence risks of antibiotics in developmentSemantic proximity Read ↗

Clinical relevance of the ESKAPE pathogensSemantic proximity Read ↗

<i>De novo</i> acquisition of antibiotic resistance in six species of bacteriaSemantic proximity Read ↗

Exceptions to the rule: Why does resistance evolution not undermine antibiotic therapy in all bacterial infections?Semantic proximity Read ↗

Mechanisms of Antibiotic Resistance.Semantic proximity Read ↗

Mutation-based mechanisms of antibiotic resistance.Semantic proximity Read ↗

Progress and Challenges in Implementing the Research on ESKAPE PathogensSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.