Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication-associated mutational asymmetry in the human genome.

Molecular biology and evolution - 1 Aug 2011

Chen Chun-Long, Duquenne Lauranne, Audit Benjamin, Guilbaud Guillaume, Rappailles Aurélien, Baker Antoine, Huvet Maxime, d'Aubenton-Carafa Yves, Hyrien Olivier, Arneodo Alain, Thermes Claude

Abstract excerpt

During evolution, mutations occur at rates that can differ between the two DNA strands. In the human genome, nucleotide substitutions occur at different rates on the transcribed and non-transcribed strands that may result from transcription-coupled repair. These mutational asymmetries generate transcription-associated compositional skews. To date, the existence of such asymmetries associated with replication has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Composition
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genome, Human

Share to Germ Cells

Share to HeLa Cells

Share to K562 Cells

Share to Organ Specificity

Source

Identifiers

PMID: 21368316
DOI: 10.1093/molbev/msr056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication-associated mutational asymmetry in the human genome.PMID 21368316Read ↗

Polymerase ζ activity is linked to replication timing in humans: evidence from mutational signaturesSemantic proximity Read ↗

Error-prone bypass of DNA lesions during lagging strand replication is a common source of germline and cancer mutationsSemantic proximity Read ↗

Replication origins drive genetic and phenotypic variation in humansSemantic proximity Read ↗

Human mutation rate associated with DNA replication timing.Semantic proximity Read ↗

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tractsSemantic proximity Read ↗

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts.Semantic proximity Read ↗

Differential relationship of DNA replication timing to different forms of human mutation and variation.Semantic proximity Read ↗

Multifactorial heterogeneity of the human mutation landscape related to DNA replication dynamicsSemantic proximity Read ↗

DNA replication initiation shapes the mutational landscape and expression of the human genome.Semantic proximity Read ↗

Exponential decay of GC content detected by strand-symmetric substitution rates influences the evolution of isochore structure.Semantic proximity Read ↗

The mutational profile of the yeast genome is shaped by replication.Semantic proximity Read ↗

The Genomic Architecture of Human DNA Replication OriginsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.