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Allele-specific analysis of DNA replication origins in mammalian cells.

Nature communications - 19 May 2015

Bartholdy Boris, Mukhopadhyay Rituparna, Lajugie Julien, Aladjem Mirit I, Bouhassira Eric E

Abstract excerpt

The mechanisms that control the location and timing of firing of replication origins are poorly understood. Using a novel functional genomic approach based on the analysis of SNPs and indels in phased human genomes, we observe that replication asynchrony is associated with small cumulative variations in the initiation efficiency of multiple origins between the chromosome homologues, rather than with the...

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Chromosomes
Computational Biology
CpG Islands
DNA Replication
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Replication Origin

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PMID: 25987481
DOI: 10.1038/ncomms8051
PMCID: PMC4479011

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