Article

Widespread impact of DNA replication on mutational mechanisms in cancer

2017-02-24

Abstract excerpt

<h4>ABSTRACT</h4> DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. Here, we use somatic mutation signatures – each representing a mutagenic process – derived from 3056 patients spanning 19 cancer types to quantify the asymmetry of mutational signatures around replication origins and between early and late replicating regions. We obs...

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Literature Corpus work: 1805ec8d-d131-5955-91a8-a02613fa506b
DOI: 10.1101/111302

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