Article
The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.
Molecular cell - 18 Aug 2016
Roulland Yohan, Ouararhni Khalid, Naidenov Mladen, Ramos Lorrie, Shuaib Muhammad, Syed Sajad Hussain, Lone Imtiaz Nizar, Boopathi Ramachandran, Fontaine Emeline, Papai Gabor, Tachiwana Hiroaki, Gautier Thierry, Skoufias Dimitrios, Padmanabhan Kiran, Bednar Jan, Kurumizaka Hitoshi, Schultz Patrick, Angelov Dimitar, Hamiche Ali, Dimitrov Stefan
Abstract excerpt
CENP-A is a histone variant, which replaces histone H3 at centromeres and confers unique properties to centromeric chromatin. The crystal structure of CENP-A nucleosome suggests flexible nucleosomal DNA ends, but their dynamics in solution remains elusive and their implication in centromere function is unknown. Using electron cryo-microscopy, we determined the dynamic solution properties of the CENP-A nucleosome....
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