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Article

The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.

Nature cell biology - 1 May 2006

Okada Masahiro, Cheeseman Iain M, Hori Tetsuya, Okawa Katsuya, McLeod Ian X, Yates John R, Desai Arshad, Fukagawa Tatsuo

Abstract excerpt

In vertebrates, centromeres lack defined sequences and are thought to be propagated by epigenetic mechanisms involving the incorporation of specialized nucleosomes containing the histone H3 variant centromere protein (CENP)-A. However, the precise mechanisms that target CENP-A to centromeres remain poorly understood. Here, we isolated a multi-subunit complex, which includes the established inner kinetochore...

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PMID: 16622420
DOI: 10.1038/ncb1396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.PMID 16622420Read ↗

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The ratio between centromeric proteins CENP-A and CENP-C maintains homeostasis of human centromeresSemantic proximity Read ↗

De novo kinetochore assembly requires the centromeric histone H3 variant.Semantic proximity Read ↗

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