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Article

A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.

Nature structural & molecular biology - 1 Aug 2015

Huang Hongda, Strømme Caroline B, Saredi Giulia, Hödl Martina, Strandsby Anne, González-Aguilera Cristina, Chen Shoudeng, Groth Anja, Patel Dinshaw J

Abstract excerpt

During DNA replication, chromatin is reassembled by recycling of modified old histones and deposition of new ones. How histone dynamics integrates with DNA replication to maintain genome and epigenome information remains unclear. Here, we reveal how human MCM2, part of the replicative helicase, chaperones histones H3-H4. Our first structure shows an H3-H4 tetramer bound by two MCM2 histone-binding domains (HBDs),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26167883
DOI: 10.1038/nsmb.3055
PMCID: PMC4685956

Genes

MCM2
CENPA
HBD

Provenance

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