Article
Structural study of the N-terminal domain of human MCM8/9 complex.
Structure (London, England : 1993) - 7 Oct 2021
Li Jun, Yu Daqi, Liu Lan, Liang Huanhuan, Ouyang Qi, Liu Yingfang
Abstract excerpt
MCM8/9 is a complex involved in homologous recombination (HR) repair pathway. MCM8/9 dysfunction can cause genome instability and result in primary ovarian insufficiency (POI). However, the mechanism underlying these effects is largely unknown. Here, we report crystal structures of the N-terminal domains (NTDs) of MCM8 and MCM9, and build a ring-shaped NTD structure based on a 6.6 Å resolution cryoelectron...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.