Article

The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners

2026-07-08

Abstract excerpt

Heterochromatin protein 1α (HP1α) is an intrinsic component of heterochromatin domains where it is involved in a diverse set of functions including heterochromatin spreading and organization, chromatin compaction and transcriptional silencing. It has been suggested that HP1α functions through a phase separation mechanism, a process that has been observed in vitro in the presence of N-terminal phosphorylation, nuc...

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Literature Corpus work: a4ceb12d-b13c-546d-9286-7e0cf7c268c6
DOI: 10.64898/2026.07.06.736852

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