Article
A Rahman Syndrome mutation in histone H1.4 disrupts chromatin compaction and phase separation.
Nature communications - 22 May 2026
Boopathi Ramachandran, Garcia-Saez Isabel, Turunç Serhan, Lone Imtiaz Nisar, Kumar Ashok, Abu Alhaija Abed Alkarem, Hayes Jeffrey J, Bednar Jan, Diril Muhammed Kasim, Iliev Dimitar, Gospodinov Anastas, Le Roy Aline, Skoufias Dimitrios, Angelov Dimitar, Hamiche Ali, Kale Seyit, Dimitrov Stefan, Petosa Carlo
Abstract excerpt
Rahman syndrome is a rare developmental disorder caused by frameshift mutations in linker histone H1.4 that produce a truncated carboxy-terminal domain with reduced positive charge. We investigated the effects of a disease-associated mutation on chromatin structure and dynamics, focusing on H1.4-bound nucleosomes and hexanucleosomal arrays. We report that this mutation induces a more extended and flexible array...
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