Article

Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction

2023-11-30

Abstract excerpt

Heterochromatin protein 1 (HP1) plays a central role in establishing and maintaining constitutive heterochromatin. However, the mechanisms underlying HP1-nucleosome interactions and their contributions to heterochromatin functions remain elusive. In this study, we employed a multidisciplinary approach to unravel the interactions between human HP1α and nucleosomes. We have elucidated the cryo-EM structure of an HP1...

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Literature Corpus work: 7b2d7273-bc75-5ebd-81a1-8cfa8b12f5e5
DOI: 10.1101/2023.11.30.569387

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