Article
53BP1 regulates heterochromatin through liquid phase separation.
Nature communications - 18 Jan 2022
Zhang Lei, Geng Xinran, Wang Fangfang, Tang Jinshan, Ichida Yu, Sharma Arishya, Jin Sora, Chen Mingyue, Tang Mingliang, Pozo Franklin Mayca, Wang Wenxiu, Wang Janet, Wozniak Michal, Guo Xiaoxia, Miyagi Masaru, Jin Fulai, Xu Yongjie, Yao Xinsheng, Zhang Youwei
Abstract excerpt
Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement in other biological process is less well understood. Here, we report a previously uncharacterized function of 53BP1 at heterochromatin, where it undergoes liquid-liquid phase separation (LLPS) with the heterochromatin protein HP1α in a mutually dependent manner. Deletion of 53BP1...
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