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Article

Phase separation as a possible mechanism for dosage sensitivity.

Genome biology - 15 Jan 2024

Yang Liang, Lyu Jiali, Li Xi, Guo Gaigai, Zhou Xueya, Chen Taoyu, Lin Yi, Li Tingting

Abstract excerpt

BACKGROUND: Deletion of haploinsufficient genes or duplication of triplosensitive ones results in phenotypic effects in a concentration-dependent manner, and the mechanisms underlying these dosage-sensitive effects remain elusive. Phase separation drives functional compartmentalization of biomolecules in a concentration-dependent manner as well, which suggests a potential link between these two processes, and...

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PMID: 38225666
DOI: 10.1186/s13059-023-03128-z
PMCID: PMC10789095

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