Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PRMT1-methylated MSX1 phase separates to control palate development.

Nature communications - 22 Jan 2025

Meng Li, Jiang Yucheng, You Jiawen, Chen Yatao, Guo Shuyu, Chen Liming, Ma Junqing

Abstract excerpt

Little is known about the regulation and function of phase separation in craniofacial developmental disorders. MSX1 mutations are associated with human cleft palate, the most common craniofacial birth defect. Here, we show that MSX1 phase separation is a vertebrate-conserved mechanism underlying embryonic palatal fusion. Notably, MSX1 phase separation is triggered by its intrinsically disordered protein region...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to MSX1 Transcription Factor
Share to Methylation
Share to Arginine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cleft Palate

Share to Gene Expression Regulation, Developmental

Share to Palate

Share to Protein-Arginine N-Methyltransferases

Share to Repressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39843447
DOI: 10.1038/s41467-025-56327-6
PMCID: PMC11754605

Genes

MSX1
PRMT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PRMT1-methylated MSX1 phase separates to control palate development.PMID 39843447Read ↗

Phase separation as a possible mechanism for dosage sensitivity.Semantic proximity Read ↗

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid LeukemiaSemantic proximity Read ↗

The role of electrostatic interactions in the phase separation of HP1α and its protein binding partnersSemantic proximity Read ↗

Disparate leukemia mutations converge on nuclear phase-separated condensates.Semantic proximity Read ↗

Protein phase separation and its role in tumorigenesis.Semantic proximity Read ↗

DDX24 Mutation Alters NPM1 Phase Behavior and Disrupts Nucleolar Homeostasis in Vascular Malformations.Semantic proximity Read ↗

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensatesSemantic proximity Read ↗

Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations.Semantic proximity Read ↗

Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation.Semantic proximity Read ↗

Condensate formation of the human RNA-binding protein SMAUG1 is controlled by its intrinsically disordered regions and interactions with 14-3-3 proteinsSemantic proximity Read ↗

Novel Strategy against AML by Rescuing Loss of Phase Separation of Pathogenic NPM1cSemantic proximity Read ↗

Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.