Article

Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer

2026-02-19

Abstract excerpt

The pathological mechanisms and significance for the prevalent hotspot mutations in disordered protein regions are poorly understood. ASXL1 is an obligate co-factor for BAP1 in H2AK119 deubiquitination. ASXL1 mutations are very frequent in myeloid malignancies, and are mostly C-terminal truncating mutations concentrated in a specific disordered region of ASXL1. ASXL1 truncations are gain-of-function mutations tha...

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Literature Corpus work: d92938c1-0db5-518a-9778-269771850a57
DOI: 10.64898/2026.02.18.706652

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