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Principles and methods for transferring polygenic risk scores across global populations.

Nature reviews. Genetics - 1 Jan 2024

Kachuri Linda, Chatterjee Nilanjan, Hirbo Jibril, Schaid Daniel J, Martin Iman, Kullo Iftikhar J, Kenny Eimear E, Pasaniuc Bogdan, Witte John S, Ge Tian

Abstract excerpt

Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait or disease and may become a valuable tool for advancing precision medicine. However, PRSs that are developed in populations of predominantly European genetic ancestries can increase health disparities due to poor predictive performance in individuals of diverse and complex genetic ancestries. We describe genetic and...

Topics

Humans
Genetic Predisposition to Disease
Risk Factors
Multifactorial Inheritance
Precision Medicine
Genome-Wide Association Study

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37620596
DOI: 10.1038/s41576-023-00637-2
PMCID: PMC10961971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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