Article

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

2020-01-15

Abstract excerpt

Polygenic scores (PGS) have been widely used to predict complex traits and risk of diseases using variants identified from genome-wide association studies (GWASs). To date, most GWASs have been conducted in populations of European ancestry, which limits the use of GWAS-derived PGS in non-European populations. Here, we develop a new theory to predict the relative accuracy (RA, relative to the accuracy in population...

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Literature Corpus work: dc663881-3236-563b-b8d2-1a4aaa44885c
DOI: 10.1101/2020.01.14.905927

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