Article

On Cross-ancestry Cancer Polygenic Risk Scores

2021-03-02

Abstract excerpt

Polygenic risk scores (PRS) can provide useful information for personalized risk stratification and disease risk assessment, especially when combined with non-genetic risk factors. However, their construction depends on the availability of summary statistics from genome-wide association studies (GWAS) independent from the target sample. For best compatibility, it was reported that GWAS and the target sample should...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54e7e325-ea5a-5b32-94b4-257bb01b409d
DOI: 10.1101/2021.02.24.21252351

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

On Cross-ancestry Cancer Polygenic Risk ScoresDOI 10.1101/2021.02.24.21252351Read

On cross-ancestry cancer polygenic risk scores.Semantic proximity Read

Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort.Semantic proximity Read

Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach.Semantic proximity Read

Predictive performance of breast cancer polygenic risk scores from diverse ancestries: a prospective study in Japanese women.Semantic proximity Read

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobankSemantic proximity Read

Inclusion of Variants Discovered from Diverse Populations Improves Polygenic Risk Score TransferabilitySemantic proximity Read

Ancestry-specific polygenic risk scores improve clinical assessments of breast cancer risk in diverse populationsSemantic proximity Read

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics.Semantic proximity Read

Principles and methods for transferring polygenic risk scores across global populations.Semantic proximity Read

Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statisticsSemantic proximity Read

Polygenic Risk Score for Cancer in African Population: A Systematic Review.Semantic proximity Read

Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry.Semantic proximity Read