Article

A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ T <sub>REG</sub> differentiation

2018-08-07

Abstract excerpt

<h4>ABSTRACT</h4> The Tec kinases ITK (interleukin-2-inducible T-cell kinase) and RLK (resting lymphocyte kinase) are critical components of the proximal TCR/CD3 signal transduction machinery, and data in mice suggest that ITK negatively regulates T REG differentiation. However, whether Tec kinases modulate T REG development and/or function in human T cells remains unknown. Using a novel self-delivery siRNA pla...

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Literature Corpus work: a47605d9-211d-5e9d-b821-a3782d84c53d
DOI: 10.1101/386508

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