Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Non-canonical NFKB signaling endows suppressive function through FOXP3-dependent regulatory T cell program

26 Nov 2023

Abstract excerpt

Regulatory T cells (Tregs) play a central role in modulating adaptive immune responses in humans and mice. The precise biological role of non-canonical nuclear factor 'κ-light-chain-enhancer' of activated B cells (NFKB) signaling in human Tregs has yet to be fully elucidated. To gain insight into this process, a Treg-like cell line (MT-2) was genetically modified using CRISPR/Cas9. Interestingly, NFKB2 knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38125410
DOI: 10.1016/j.heliyon.2023.e22911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Non-canonical NFKB signaling endows suppressive function through FOXP3-dependent regulatory T cell programPMID 38125410Read ↗

Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identitySemantic proximity Read ↗

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity.Semantic proximity Read ↗

Co-Expression of FOXP3FL and FOXP3Δ2 Isoforms Is Required for Optimal Treg-Like Cell Phenotypes and Suppressive Function.Semantic proximity Read ↗

Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cellsSemantic proximity Read ↗

Regulatory T cells and Foxp3.Semantic proximity Read ↗

Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.Semantic proximity Read ↗

A genome-wide CRISPR screen reveals a role for the BRD9-containing non-canonical BAF complex in regulatory T cellsSemantic proximity Read ↗

Defects in CD8 <sup>+</sup> T cell suppression by Foxp3-ΔE2 expressing regulatory T cellsSemantic proximity Read ↗

Molecular control of regulatory T cell development and function.Semantic proximity Read ↗

CRISPR Screen in Regulatory T Cells Reveals Ubiquitination Modulators of Foxp3Semantic proximity Read ↗

Foxp3 in the Immune SystemSemantic proximity Read ↗

Cis-Regulatory Element and Transcription Factor Circuitry Required for Cell-Type Specific Expression of FOXP3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.