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Article

Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis

18 Aug 2020

Abstract excerpt

ITK (IL-2-inducible tyrosine kinase) belongs to the Tec family kinases and is mainly expressed in T cells. It is involved in TCR signalling events driving processes like T cell development as well as Th2, Th9 and Th17 responses thereby controlling the expression of pro-inflammatory cytokines. Studies have shown that ITK is involved in the pathogenesis of autoimmune diseases as well as in carcinogenesis. The loss...

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PMID: 32808093
DOI: 10.1007/s00109-020-01958-z

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