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Article

First insight into the kinome of human regulatory T cells.

PloS one - 1 Jan 2012

König Sebastian, Probst-Kepper Michael, Reinl Tobias, Jeron Andreas, Huehn Jochen, Schraven Burkhart, Jänsch Lothar

Abstract excerpt

Regulatory T cells (Tregs) are essential for controlling peripheral tolerance by the active suppression of various immune cells including conventional T effector cells (Teffs). Downstream of the T cell receptor (TCR), more than 500 protein kinases encoded by the human genome have to be considered in signaling cascades regulating the activation of Tregs and Teffs, respectively. Following TCR engagement, Tregs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22815858
DOI: 10.1371/journal.pone.0040896
PMCID: PMC3397934

Genes

CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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