Article
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
Immunity - 1 Jul 2006
Atherly Luana O, Lucas Julie A, Felices Martin, Yin Catherine C, Reiner Steven L, Berg Leslie J
Abstract excerpt
The Tec family tyrosine kinases, Itk and Rlk, are expressed in thymocytes and peripheral T cells and regulate thresholds of T cell receptor signaling. Yet little is known about the specific role of Itk- and Rlk-dependent signals in CD8(+) T cell maturation. We show here that Itk(-/-) and Rlk(-/-)Itk(-/-) mice were nearly devoid of conventional CD8(+) T cells and, instead, contained a large population of CD8(+) T...
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