Article

LCK deficiency in CD8 T cells leads to reduced proliferation and increased effector T-cell formation in mice

2025-09-02

Abstract excerpt

LCK is an SRC-family kinase that mediates the initial steps in T-cell antigen receptor signaling and governs positive and negative selection during thymocyte development. While its developmental role is well established, its functions in peripheral T-cell responses remain poorly defined. Here, we investigated the responses of wild-type and LCK-deficient TCR-transgenic OT-I T cells across two infection models and a...

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Literature Corpus work: 054526cb-dfe9-5c0a-950d-c87fe9aae61e
DOI: 10.1101/2025.08.28.672860

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