Article

TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation

2024-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Janus kinase (JAK) inhibitors are widely use to inhibit inflammatory cytokine signalling in autoimmune and inflammatory diseases but their effect on regulatory T cells (Tregs) is poorly characterized. We investigated the effect of JAK inhibition on human Treg differentiation, phenotype, and function using a JAK inhibitor, upadacitinib, in comparison to BMS-986202, a selective Tyrosine kinase 2 (...

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Literature Corpus work: e87cb43c-30eb-5129-8d36-7f7910773b11
DOI: 10.1101/2024.10.01.616157

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