Article

Targeting ion channel TRPM7 promotes thymic development of Regulatory T cells by increasing IL-2-dependent STAT5 activation

2018-05-25

Abstract excerpt

<h4>In Brief</h4> Genetic deletion of Trpm7 in T-cells or pharmacological inhibition of TRPM7 channel promotes the development of fully functional T reg cells by increasing IL-2Rα and STAT5-dependent FOXP3 expression in the developing thymocytes. The study identifies the ion channel TRPM7 as a putative drug target to increase T reg numbers in vivo and induce immunotolerance. <h4>HIGHLIGHTS</h4> Ion channel...

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Literature Corpus work: f5d92dc5-fca7-56ed-b2d3-1d15260d8e14
DOI: 10.1101/330233

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