Article

Understanding the genetic risks of complex diseases using the additive epistatic interaction model: a simulation study

2019-12-04

Abstract excerpt

Thousands of Genome-Wide Association Studies (GWAS) have been carried out to pinpoint genetic variants associated with complex diseases. However, the proportion of phenotypic variance which can be explained by the identified genetic variants is relatively low, leading to the “missing heritability” problem. This problem may be partly caused by the inadequate understanding of the genetic mechanisms of complex diseas...

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Literature Corpus work: a43431c7-abe2-5ee4-b22d-94ca87f5e744
DOI: 10.1101/865196

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