On epistasis: a methodological review for detecting gene-gene interactions underlying various types of phenotypic traits.

Abstract excerpt

Genome-wide association study (GWAS) has become a commonly adopted approach for revealing the genetic architecture of complex diseases, with respect to uncovering the unknown genetic variants involved in the disease, their variations in the population and the magnitude of their effects. Though a substantial number of disease-susceptibility variants have been identified, the genetic architecture of complex...

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