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Article

Poor statistical power in population-based association study of gene interaction.

BMC medical genomics - 27 Apr 2024

Ma Jiarui, Li Jian, Chen Yuqi, Yang Zhen, He Yungang

Abstract excerpt

BACKGROUND: Statistical epistasis, or "gene-gene interaction" in genetic association studies, means the nonadditive effects between the polymorphic sites on two different genes affecting the same phenotype. In the genetic association analysis of complex traits, nevertheless, the researchers haven't found enough clues of statistical epistasis so far. METHODS: We developed a statistical model where the statistical...

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Identifiers

PMID: 38678264
DOI: 10.1186/s12920-024-01884-w
PMCID: PMC11055307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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