Article

A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis

2023-09-12

Abstract excerpt

The contribution of epistasis (interactions among genes or genetic variants) to human complex trait variation remains poorly understood. Methods that aim to explicitly identify pairs of genetic variants, usually single nucleotide polymorphisms (SNPs), associated with a trait suffer from low power due to the large number of hypotheses tested while also having to deal with the computational problem of searching over...

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Literature Corpus work: 0bfa3c71-d329-5c9c-9955-579dc8f54d74
DOI: 10.1101/2023.09.10.557084

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