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Article

A model and test for coordinated polygenic epistasis in complex traits.

Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2021

Sheppard Brooke, Rappoport Nadav, Loh Po-Ru, Sanders Stephan J, Zaitlen Noah, Dahl Andy

Abstract excerpt

Interactions between genetic variants-epistasis-is pervasive in model systems and can profoundly impact evolutionary adaption, population disease dynamics, genetic mapping, and precision medicine efforts. In this work, we develop a model for structured polygenic epistasis, called coordinated epistasis (CE), and prove that several recent theories of genetic architecture fall under the formal umbrella of CE. Unlike...

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Share to Epistasis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Models, Genetic

Share to Multifactorial Inheritance

Share to Quantitative Trait, Heritable

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Identifiers

PMID: 33833052
DOI: 10.1073/pnas.1922305118
PMCID: PMC8053945

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