Analysis of Gene-Gene Interactions.

doi:10.1002/cphg.45

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Article

Analysis of Gene-Gene Interactions.

Current protocols in human genetics - 18 Oct 2017

Cole Brian S, Hall Molly A, Urbanowicz Ryan J, Gilbert-Diamond Diane, Moore Jason H

Abstract excerpt

The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for...

Topics

Algorithms
Animals
Epistasis, Genetic
Gene Expression Regulation
Genetic Association Studies
Genetic Predisposition to Disease
Genomics
Humans
Machine Learning
Models, Statistical

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Open in PubMed

Identifiers

PMID: 29044470
DOI: 10.1002/cphg.45

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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