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Article

Deep learning captures the effect of epistasis in multifactorial diseases

7 Jan 2025

Abstract excerpt

Background: Polygenic risk score (PRS) prediction is widely used to assess the risk of diagnosis and progression of many diseases. Routinely, the weights of individual SNPs are estimated by the linear regression model that assumes independent and linear contribution of each SNP to the phenotype. However, for complex multifactorial diseases such as Alzheimer's disease, diabetes, cardiovascular disease, cancer, and...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39839630
DOI: 10.3389/fmed.2024.1479717

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