Article
GenEpi: gene-based epistasis discovery using machine learning.
BMC bioinformatics - 24 Feb 2020
Chang Yu-Chuan, Wu June-Tai, Hong Ming-Yi, Tung Yi-An, Hsieh Ping-Han, Yee Sook Wah, Giacomini Kathleen M, Oyang Yen-Jen, Chen Chien-Yu
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) provide a powerful means to identify associations between genetic variants and phenotypes. However, GWAS techniques for detecting epistasis, the interactions between genetic variants associated with phenotypes, are still limited. We believe that developing an efficient and effective GWAS method to detect epistasis will be a key for discovering sophisticated...
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