Article

Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) mice

2022-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) poses an ever-increasing public health concern as the population ages, affecting more than 6 million Americans. AD patients present with mood and sleep changes in the prodromal stages that may be partly driven by loss of monoaminergic neurons in brainstem, but a causal relationship has not been firmly established. The goal of the present study was to evaluate depressive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a418233c-87d7-56ac-90b0-c0ac3a69ae45
DOI: 10.1101/2022.04.03.486898

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) miceDOI 10.1101/2022.04.03.486898Read

Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia.Semantic proximity Read

A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout lifeSemantic proximity Read

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s diseaseSemantic proximity Read

Triiodothyronine Treatment Reverses Depression-Like Behavior in a Triple-Transgenic Animal Model of Alzheimer’s Disease.Semantic proximity Read

Behavioral Abnormalities in Knockout and Humanized Tau MiceSemantic proximity Read

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice.Semantic proximity Read

Enhanced Hippocampal Spare Capacity in Q175DN Mice Despite Elevated mHTT AggregationSemantic proximity Read

Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathySemantic proximity Read

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.Semantic proximity Read

Glial and BBB modifications correlate with early anxio-depressive-like behaviors and cognitive inflexibility in 3xTg-AD miceSemantic proximity Read

Consequences of endogenous and virally-induced hyperphosphorylated tau on behavior and cognition in a rat model of Alzheimer’s diseaseSemantic proximity Read

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Semantic proximity Read