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Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia.

Behavioural brain research - 1 Apr 2013

Van der Jeugd Ann, Blum David, Raison Sylvie, Eddarkaoui Sabiha, Buée Luc, D'Hooge Rudi

Abstract excerpt

THY-Tau22 mice constitute an animal model for tau aggregation, a hallmark in Alzheimer's disease (AD) and Tauopathies. Our previous studies have shown learning and memory deficits and changes in synaptic plasticity in the hippocampus in THY-Tau22 mice that are consistent with the learning impairments seen in AD-patients. However, behavioral disturbances are the most important problems in the management of AD and...

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Source

Identifiers

PMID: 23247080
DOI: 10.1016/j.bbr.2012.12.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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