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Glial and BBB modifications correlate with early anxio-depressive-like behaviors and cognitive inflexibility in 3xTg-AD mice

2026-03-17

Abstract excerpt

Multiple lines of evidence indicate that alterations in glial cells and the blood-brain barrier (BBB) contribute to anxiety- and depression-like behaviors in murine models of depression and chronic stress. Although behavioral and psychological symptoms of dementia (BPSD) represent a major feature of Alzheimer’s disease (AD), this relationship has received limited attention in this pathology. Using the 3xTg-AD mous...

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Literature Corpus work
51441a11-031f-5bdb-a406-19255cc59bbe
DOI
10.64898/2026.03.13.711598
Open publication

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Glial and BBB modifications correlate with early anxio-depressive-like behaviors and cognitive inflexibility in 3xTg-AD miceDOI 10.64898/2026.03.13.711598
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