Article

Consequences of endogenous and virally-induced hyperphosphorylated tau on behavior and cognition in a rat model of Alzheimer’s disease

2021-11-02

Abstract excerpt

<h4>Background</h4> The locus coeruleus (LC) is one of the earliest brain regions to accumulate hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has hampered our ability to understand its contributions to the pathophysiology of Alzheimer’s disease (AD). <h4>Objective</h4> We previously reported that TgF344-AD rats, which overexpress mutant human amyloid precursor protein and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f992a9e1-6168-53a3-beab-00cb95391f34
DOI: 10.1101/2021.10.30.466530

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Consequences of endogenous and virally-induced hyperphosphorylated tau on behavior and cognition in a rat model of Alzheimer’s diseaseDOI 10.1101/2021.10.30.466530Read

Impact of early locus coeruleus lesions in the TgF344 Alzheimer’s disease rat modelSemantic proximity Read

Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of early Alzheimer’s diseaseSemantic proximity Read

Sex- and age-dependent effects of locus coeruleus-originated tau dysfunction on olfaction and neurophysiology in ratsSemantic proximity Read

Locus coeruleus vulnerability to tau hyperphosphorylation in a rat modelSemantic proximity Read

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease ResearchSemantic proximity Read

Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic MiceSemantic proximity Read

A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout lifeSemantic proximity Read

Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) miceSemantic proximity Read

Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathySemantic proximity Read

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal LossSemantic proximity Read

Modeling Alzheimer's disease with non-transgenic rat modelsSemantic proximity Read

Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.Semantic proximity Read