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Article

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice.

Brain research - 12 Oct 2005

Egashira Nobuaki, Iwasaki Katsunori, Takashima Akihiko, Watanabe Takuya, Kawabe Hideyuki, Matsuda Tomomi, Mishima Kenichi, Chidori Shozo, Nishimura Ryoji, Fujiwara Michihiro

Abstract excerpt

Mutant R406W human tau was originally identified in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and causes a hereditary tauopathy that clinically resembles Alzheimer's disease (AD). In the current study, we examined the performance of R406W transgenic (Tg) mice in the forced swimming test, a test with high predictivity of antidepressant efficacy in human depression, and found an...

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PMID: 16182262
DOI: 10.1016/j.brainres.2005.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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