Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy

1 Oct 2023

Abstract excerpt

In tauopathies such as Alzheimer's disease (AD) and frontotemporal dementia (FTD), the microtubule associated protein tau undergoes conformational and posttranslational modifications in a gradual, staged pathological process. While brain atrophy and cognitive decline are well-established in the advanced stages of tauopathy, it is unclear how the early pathological processes manifest prior to extensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37802153
DOI: 10.1016/j.nbd.2023.106317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathyPMID 37802153Read ↗

A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.Semantic proximity Read ↗

Characterization of a novel transgenic rat carrying human tau with mutation P301L.Semantic proximity Read ↗

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.Semantic proximity Read ↗

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read ↗

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelSemantic proximity Read ↗

Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology.Semantic proximity Read ↗

Transgenic mice as a model of pre-clinical Alzheimer's disease.Semantic proximity Read ↗

Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD.Semantic proximity Read ↗

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.Semantic proximity Read ↗

Common mouse models of tauopathy reflect early but not late human diseaseSemantic proximity Read ↗

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degenerationSemantic proximity Read ↗

Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic ratsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.