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Behavioral Abnormalities in Knockout and Humanized Tau Mice

12 Mar 2020

Abstract excerpt

Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervous system (CNS). Our group has previously shown that tau ablation triggers glucose intolerance and...

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PMID: 32226410
DOI: 10.3389/fendo.2020.00124

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