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A TauP301L mouse model of dementia; development of pathology, synaptic transmission, microglial response and cognition throughout life

2018-09-17

Abstract excerpt

<h4>Background</h4> Late stage Alzheimer’s disease and other dementias are associated with neurofibrillary tangles and neurodegeneration. Here we describe a mouse (TauD35) carrying human Tau with the P301L mutation that results in Tau hyperphosphorylation and tangles. Previously we have compared gene expression in TauD35 mice to mice which develop plaques but no tangles. A similar comparison of other pathological...

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Literature Corpus work
800c93e8-42b0-5d0e-be4c-298660f51989
DOI
10.1101/420398
Open publication

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