Article

MMEJ-based Precision Gene Editing for applications in Gene Therapy and Functional Genomics

2020-04-25

Abstract excerpt

<h4>ABSTRACT</h4> Experiments in gene editing commonly elicit error-prone non-homologous end joining for DNA double-strand break (DSB) repair. Microhomology-mediated end joining (MMEJ) can generate more predictable outcomes for functional genomic and somatic therapeutic applications. MENTHU is a computational tool that predicts nuclease-targetable sites likely to result in MMEJ-repaired, homogeneous genotypes (Pr...

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Literature Corpus work: 0c771f86-54d6-5089-b257-804a1541ccf3
DOI: 10.1101/2020.04.25.060541

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