Article

Resolving subcellular pH with a quantitative fluorescent lifetime biosensor

2022-04-13

Abstract excerpt

Changes in sub-cellular pH play a key role in metabolism, cell growth, membrane transport, and can also be exploited to control cargo release from therapeutic delivery systems. Most methods to measure pH rely on intensity changes of pH sensitive fluorophores, however these measurements are hampered by high uncertainty in the inferred pH and the need for multiple fluorophores. To address this, we have developed a m...

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Literature Corpus work: a3cb5e65-4267-5063-b616-ed583303282e
DOI: 10.1101/2022.04.13.488146

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