Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acidic pH of early endosomes governs SARS-CoV-2 transport in host cells

26 Dec 2024

Abstract excerpt

Endocytosis is a prominent mechanism for SARS-CoV-2 entry into host cells. Upon internalization into early endosomes (EEs), the virus is transported to late endosomes (LEs), where acidic conditions facilitate spike protein processing and viral genome release. Dynein and kinesin motors drive EE transport along microtubules; dynein moves EEs to the perinuclear region, while kinesins direct them towards the plasma...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Lipid Membrane Structure and Behavior
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39732172
DOI: 10.1016/j.jbc.2024.108144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acidic pH of early endosomes governs SARS-CoV-2 transport in host cellsPMID 39732172Read ↗

SARS-CoV-2 infection alkalinizes the ERGIC and lysosomes through the viroporin activity of the viral envelope proteinSemantic proximity Read ↗

The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking.Semantic proximity Read ↗

Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infectionSemantic proximity Read ↗

CLIC and membrane wound repair pathways enable pandemic norovirus entry and infectionSemantic proximity Read ↗

Enterovirus D68 capsid formation and stability requires acidic compartmentsSemantic proximity Read ↗

Dynamic Nucleolar Targeting of Dengue Virus Polymerase NS5 in Response to Extracellular pH.Semantic proximity Read ↗

Distinct motifs in the E protein are required for SARS-CoV-2 virus particle formation and lysosomal deacidification in host cellsSemantic proximity Read ↗

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding DomainsSemantic proximity Read ↗

Exo70 promotes herpesvirus secretory vesicle tethering and virion release in an exocyst complex-dependent mannerSemantic proximity Read ↗

Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal traffickingSemantic proximity Read ↗

Direct endosomal acidification by the outwardly rectifying CLC-5 Cl(-)/H(+) exchanger.Semantic proximity Read ↗

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.