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pHLARE: A Genetically Encoded Ratiometric Lysosome pH Biosensor

2020-06-04

Abstract excerpt

Many lysosome functions are determined by a lumenal pH of ~5.0, including the activity of resident acid-activated hydrolases. Lysosome pH (pHlys) is increased in neurodegenerative disorders and predicted to be decreased in cancers, making it a potential target for therapeutics to limit the progression of these diseases. Accurately measuring pHlys, however, is limited by currently used dyes that accumulate in multi...

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Literature Corpus work
ba407a3d-9105-5cec-988d-9eefbd7f7104
DOI
10.1101/2020.06.03.132720
Open publication

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pHLARE: A Genetically Encoded Ratiometric Lysosome pH BiosensorDOI 10.1101/2020.06.03.132720
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