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Article

SCO-ph: Microfluidic Dynamic Phenotyping Platform for High-Throughput Screening of Single Cell Acidification.

Small (Weinheim an der Bergstrasse, Germany) - 1 Aug 2025

Jeong Hyejoong, Leyes Porello Emilia A, Rosario Jean G, Kuang Da, Han Syung Hun, Sul Jai-Yoon, Lim Bomyi, Lee Daeyeon, Kim Junhyong

Abstract excerpt

Studies on the dynamics of single cell phenotyping have been hampered by the lack of quantitative high-throughput metabolism assays. Extracellular acidification, a prominent phenotype, yields significant insights into cellular metabolism, including tumorigenicity. Here, it is developed a versatile microfluidic system for single cell optical pH analysis (SCO-pH), which compartmentalizes single cells in 140-pL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40519058
DOI: 10.1002/smll.202504687
PMCID: PMC12366287

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